PHARMACOLOGICAL OPERATION: Pharmacodynamics:
Raunatin contains complex of Rauvolfia alkaloids: reserpine, serpentine, ajmaline and etc.
Raunatin has hypotensive action, which is conditioned by the reduction of biogenic monoamines (noradrenaline, dopamine, serotonin) concentration in the Central Nervous System. By the violation of mediators’ deposition process in the presynaptic terminals, the preparation blocks adrenergic transmission (innervation), which causes gradual reduction of blood pressure. The peculiarity of the drug is increase of kidney’s glomerular filtration and accordingly increases of blood supply. Raunatin has also antiarrhythmic action, it restores excitation and patency processes in the heart muscle. It has soothing action on the Central Nervous System. Therapeutic effect of the preparation reveals gradually. During 10-14 days from the beginning of treatment and maintains during 2-3 months.
Pharmacokinetics: Alkaloids of the preparations are well absorbed from the gastrointestinal tract. Maximal concentration is achieved after 1-2 hours from intake. 40-50% of the preparation relates to blood plasma proteins. Semiejection period makes up 50-170 hours. Metabolizes in the liver and spleen. Basically eliminated with excrements and urine.

• Rauwolfia alkaloids complex 2 mg (reserpine, serpentine, ajmaline, and others)
• Excipients: lactose, starch, talc, calcium stearate

Take orally after meals, starting with 1 tablet (2 mg) 3 times daily for the first 1–2 weeks. The dose may be gradually increased as directed by a physician, up to a maximum of 4–6 tablets per day. The therapeutic effect develops gradually over 10–14 days from the start of treatment. Duration of therapy is determined by the physician.

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